Dupagne was a pupil of Adrien de Witte, Oscar Berchmans and Evariste Carpentier at the Academy of Fine Arts in Liege. He graduated in 1910 in sculpture but following the advice of his teachers he was introduced to painting. In 1912 he was in London and worked as a sculptor in the decoration of the Titanic; in 1913 he was in Paris and by 1924 he was exhibiting at the Venice Biennale. He excelled in the art of representing figures, his preferred subject was the female nude. A grand traveller, he visited many countries throughout Europe, the Middle East, North Africa and America resulting in a large body of work recording life in the countries he visited. Dupagne successively exhibited at Devambez, Bernheim Jeune and Georges Aubry and his paintings are exhibited in museums in Brussels, Antwerp and Liege.